BAG1 Polyclonal Antibody (E-AB-13861)
For research use only.
| Verified Samples |
Verified Samples in WB: Hela, K562, Raji Verified Samples in IHC: Human thyroid cancer |
| Dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human BAG1 |
| Abbre | BAG1 |
| Synonyms | BAG family molecular chaperone regulator 1, BAG-1, BAG1, BCL 2 Associated Athanogene 1, BCL 2 associated athanogene, BCL 2 binding athanogene 1, BCL2 associated athanogene, BCL2 associated athanogene 1, Bag 1, Bcl-2-associated athanogene 1, Glucocorticoid rece |
| Swissprot | |
| Calculated MW | 39 kDa |
| Cellular Localization | Cytoplasm, Nucleus, Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock, Nucleus, Cytoplasm, Isoform 1 localizes predominantly to the nucleus and Cytoplasm, Nucleus, Isoform 4 localizes predominantly to the cytoplasm, The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus, In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria. |
| Concentration | 0.2 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Cardiovascular, Metabolism |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. |
Other Clones
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Other Formats
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Unconjugated
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