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For research use only.

Verified Samples Verified Samples in WB: Human brain malignant glioma, MCF-7, Raji, LoVo
Verified Samples in IHC: Human esophagus cancer, Human lung cancer
Dilution WB 1:500-1:2000,  IHC 1:25-1:100
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse,  Rat
Applications WB,  IHC
Clonality Polyclonal
Immunogen Recombinant protein of human BAX
Abbre BAX
Synonyms Apoptosis regulator BAX,  BAX,  BAXA,  BCL2 associated X protein,  BCL2 associated X protein omega,  BCL2 associated X protein transcript variant delta2,  BCL2L4,  Bax-protein,  Baxdelta2G9,  Baxdelta2G9omega,  Baxdelta2omega,  Bcl-2-like protein 4,  Bcl2-L-4,  membrane isofor
Swissprot
Calculated MW 21 kDa
Cellular Localization Cytoplasm and Mitochondrion membrane. Cytoplasm. Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane.
Concentration 0.2 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer,  Cell Biology,  Metabolism
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
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Unconjugated

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