Biotin Anti-Human CD274/PD-L1 Antibody[29E.2A3] (E-AB-F1133B)
![Biotin Anti-Human CD274/PD-L1 Antibody[29E.2A3] - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
Conjugation: Biotin
APC Biotin Elab Fluor®700 FITC None (AF/LE) PE PE/Cyanine 5 PE/Cyanine 7 PerCP/Cyanine 5.5 Unconjugated Show More
| Isotype | Mouse IgG2b, κ |
| Host | Mouse |
| Reactivity | Human |
| Applications | FCM |
| Clonality | Monoclonal |
| Abbre | PD-L1 |
| Synonyms | B7H1PD-L1PDCD1L1PDCD1LG1PDL1, B7 homolog 1, B7-H, B7-H1, Programmed cell death ligand 1 |
| Swissprot | |
| Cellular Localization | Membrane |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Research Areas | Cancer Biomarkers, Costimulatory Molecules, Immunology |
| Clone No. | 29E.2A3 |
| Conjugation | Biotin |
| Storage | This product can be stored at 2-8°C for 12 months. Do not freeze. |
| Shipping | Ice bag |
| background | CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells. |
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