Biotin Anti-Mouse IL-17A Antibody[TC11-18H10.1] (E-AB-F1199B)
                        For research use only.
| Alternate Names | CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, Interleukin-17A | 
| Clone No | |
| Leadtime | Order now, ship in 3 days | 
| Background | IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course. | 
| Abbre | IL-17A | 
| Swissprot | |
| Host | Rat | 
| Reactivity | Mouse | 
| Clonality | Monoclonal | 
| Isotype | Rat IgG1, κ | 
| Isotype Control | E-AB-F09823B | 
| Applications | 
                         
                ICFCM             
         | 
    
| Research Areas | Cell Biology;Immunology;Neuroinflammation;Neuroscience | 
| Cellular Localization | 
             
                Secreted             
         | 
    
| Form | Liquid | 
| Concentration | 
             
                0.5 mg/mL             
         | 
    
| Conjugation | Biotin | 
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. | 
| Storage | This product can be stored at 2-8°C for 12 months. Do not freeze. | 
| Expiration Date | 12 months | 
| Shipping | Ice bag | 
Other Clones
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Other Formats
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APC
Biotin
Elab Fluor®647
Elab Fluor®700
Elab Fluor®Violet 450
FITC
None (AF/LE)
None (AF/LE)
PE
PE/Cyanine 7
Unconjugated
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