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For research use only.

Verified Samples Verified Samples in IHC: Human lung cancer, Human gastric cancer, Rat heart, Rat testis, Rat kidney, Rat spleen
Verified Samples in IF: HeLa, NIH/3T3, PC12
Dilution IHC 1:50-1:200,  IF 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse,  Rat
Applications IHC,  IF
Clonality Polyclonal
Immunogen A synthetic peptide of human Caspase-3 (NP_004337.2).
Synonyms Active Caspase 3,  CASP3,  CPP32,  CPP32B,  Caspase 3,  Caspase-3 p12,  SCA-1,  active Caspase-3,  caspase-3
Swissprot
Cellular Localization Cytoplasm.
Concentration 1 mg/mL
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Affinity purification
Research Areas Cancer,  Cell Biology,  Metabolism,  Neuroscience
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
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Unconjugated

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