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For research use only.

Verified Samples Verified Samples in WB: LoVo
Verified Samples in IHC: Human cervical cancer, Human colon cancer
Dilution WB 1:500-1:2000,  IHC 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Human
Applications WB,  IHC
Clonality Polyclonal
Immunogen Recombinant protein of human CAST
Abbre CAST
Synonyms BS 17,  Calpain inhibitor,  Calpastatin,  Cast,  Heart type calpastatin,  ICAL,  MGC9402,  Sperm BS 17 component,  Sperm BS-17 component
Swissprot
Calculated MW 77 kDa
Cellular Localization Cytosol, Endoplasmic reticulum, endoplasmic reticulum, Other locations: membrane.
Concentration 0.7 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer,  Cell Biology,  Neuroscience
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
Other Clones

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Unconjugated

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