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For research use only.

Verified Samples Verified Samples in IHC: Human colon cancer, Human cervical cancer
Dilution IHC 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse
Applications IHC
Clonality Polyclonal
Immunogen Recombinant protein of human CCDC106
Abbre CCDC106
Synonyms CC106,  Ccdc106,  Coiled-coil domain-containing protein 106,  HSU79303,  Protein predicted by clone 23882,  ZNF581
Swissprot
Cellular Localization Nucleus. Colocalizes with p53/TP53.
Concentration 0.5 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation, indicating that at least one of the functions of CCDC106 is acting as a negative regulator of p53.
Other Clones

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Unconjugated

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