CD105 Polyclonal Antibody (D-AB-10448L)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human placenta |
| Dilution | IHC 1:1000-1:2000 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant Mouse CD105 protein expressed by E.coli |
| Abbre | CD105 |
| Synonyms | AI528660, AI662476, CD 105, CD105, CD105 antigen, EGLN, END, Endoglin, Eng, FLJ41744, HHT1, ORW, ORW1, Osler Rendu Weber syndrome 1, RP11 228B15.2, S-endoglin, SN6 |
| Swissprot | |
| Cellular Localization | Cell membrane |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Immunology, Stem Cells, Cancer, Cardiovascular, Antibody Arrays, Developmental Biology, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin and betaglycan/T beta RIII are type III receptors for TGF beta superfamily ligands,sharing 71% aa identity in the transmembrane (TM) and cytoplasmic domains. Endoglin is highly expressed on proliferating vascular endothelial cells,chondrocytes,and syncytiotrophoblasts of term placenta,with lower amounts on hematopoietic,mesenchymal and neural crest stem cells,activated monocytes,and lymphoid and myeloid leukemic cells. Human endoglin cDNA encodes 658 amino acids (aa) including a 25 aa signal sequence,a 561 aa extracellular domain (ECD) with an orphan domain and a two-part ZP domain,a TM domain and a 47 aa cytoplasmic domain. An isoform with a 14 aa cytoplasmic domain (S-endoglin) can oppose effects of long (l) endoglin. The human endoglin ECD shares 65-72% aa identity with mouse,rat,bovine,porcine and canine endoglin. Endoglin homodimers interact with TGF-beta 1 and TGF-beta 3 (but not TGF-beta 2),but only after binding T beta RII. Similarly,they interact with Activin A and BMP-7 via activin type IIA or B receptors,and with BMP-2 via BMPR-IA/AlK-3 or BMPR-IB/AlK-6. BMP-9,however,is reported to bind endoglin directly. Endoglin modifies ligand-induced signaling in multiple ways. For example,expression of endoglin can inhibit TGF-beta 1 signals but enhance BMP-7 signals in the same myoblast cell line |
Other Clones
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Other Formats
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Unconjugated
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