CD113/Nectin-3 Monoclonal Antibody (AN200188P)
For research use only.
| Verified Samples | Verified Samples in IHC: Human placenta, Human hepatoma, cynomolgus testis |
| Dilution | IHC-P 1:50-1:200 |
| Isotype | IgG1 |
| Host | Mouse |
| Reactivity | Human |
| Applications | IHC-P |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human CD113/Nectin-3 protein |
| Abbre | NECTIN3 |
| Synonyms | PRR, CDw, PPR, PVRL, Poliovirus receptor-like, Poliovirus receptor related, Poliovirus receptor related protein, PVRR, DKFZP566B, CD113, CDw113, DKFZP566B0846, FLJ90624, Nectin-3, Poliovirus receptor related 3, Poliovirus receptor related protein 3, Poliovirus receptor-like 3, Poliovirus Receptor-Related Protein 3, PPR3, PVRR3, PRR3, PVRL3, NECTIN3, Nectin-3, PRR3, CDw113 |
| Swissprot | |
| Tissue Specificity | Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines. |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Research Areas | Immunology, Microbiology |
| Clone No. | A1040 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | Poliovirus receptor-related 3 (PVRL3), also known as Nectin-3 and CD113, is a member of the nectin family. PVRL3/Nectin-3 is an 83 kDa, type I transmembrane glycoprotein. Its precursor is 549 amino acids (aa) in length and contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa, and a cytoplasmic region of 124 aa. Nectin-3 has three splicing variants, nectin-3alpha (biggest), -3beta (middle), and -3gamma (smallest). It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. PVRL3/Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. PVRL3/Nectin-3 is thus involved in the formation of cell-cell junctions, including adherens junctions and synapses. It has been shown to induce endocytosis-mediated down-regulation of PVR from the cell surface, resulting in the reduction of cell movement and proliferation. |
Other Clones
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Unconjugated
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