CDH12 Polyclonal Antibody (E-AB-19682)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Human brain, Human ovarian cancer |
| Dilution | IHC 1:50-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human CDH12 |
| Abbre | CDH12 |
| Synonyms | BR-cadherin, Br cadherin, Brain cadherin, CAD12_HUMAN, CDH12, CDHB, Cadherin 12, Cadherin 12 precursor, Cadherin 12 type 2, Cadherin 12 type 2 (N cadherin 2), Cadherin neural type 2, Cadherin-12, FLJ34857, N cadherin 2, N-cadherin 2, Neural ty, cadherin 12 (N cadherin 2) |
| Swissprot | |
| Cellular Localization | Membrane |
| Concentration | 1.74 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. |
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