Claudin18.2 Monoclonal Antibody (AN200149P)
For research use only.
| Verified Samples |
Verified Samples in WB: Human Claudin18.2-VLP (Full Length) Protein, Virus-Like Particle (VLP) isotype control Protein Verified Samples in IHC: Human stomach, Human lung, Human gastric cancer |
| Dilution | WB 1:500-1:2000, IHC-P 1:500-1:2000 |
| Isotype | Mouse IgG2a |
| Host | Mouse |
| Reactivity | Human |
| Applications | WB, IHC-P |
| Clonality | Monoclonal |
| Immunogen | Human Claudin18.2 mRNA |
| Abbre | CLDN18 |
| Synonyms | Claudin, Claudin-, Claudin-18, Claudin-18.2, CLDN, CLDN18, PRO, PRO1572, SFTA, SFTA5, SFTPJ, SPJ, UNQ, UNQ778 |
| Swissprot | |
| Calculated MW | 27.9 kDa |
| Cellular Localization | Cell junction, Cell membrane |
| Tissue Specificity | [Isoform A1]: Expression is restricted to the lung. |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS. |
| Purification Method | Protein A affinity purification |
| Research Areas | Signal Transduction |
| Clone | A1001 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-2) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Note: Data for this module come from published literature that cites this product, displaying other products used together in the same research paper.
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