CRACR2A Polyclonal Antibody (E-AB-19269)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human brain |
| Dilution | IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human CRACR2A |
| Abbre | CRACR2A |
| Synonyms | CRAC channel regulator 2A, CRACR2A, Calcium release-activated calcium channel regulator 2A, EF hand calcium binding domain 4B, EF hand calcium binding domain containing protein 4B, EF-hand calcium-binding domain-containing protein 4B, EFC4B, EFCAB 4B, Efcab4b, FLJ |
| Swissprot | |
| Cellular Localization | Cytoplasm. |
| Concentration | 0.84 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Ca2+-binding protein that plays a key role in store-operated Ca2+ entry (SOCE) in T-cells by regulating CRAC channel activation.Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration.It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1.Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. |
Other Clones
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Other Formats
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Unconjugated
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