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For research use only.

Verified Samples Verified Samples in IHC: Human gastric cancer, Human thyroid cancer
Dilution IHC 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Human
Applications IHC
Clonality Polyclonal
Immunogen Synthetic peptide of human CYP2D6
Abbre CYP2D6
Synonyms CPD6,  CYP2D,  CYP2D6,  CYP2D7AP,  CYP2D7BP,  CYP2D7P2,  CYP2D8P2,  CYP2DL1,  CYPIID6,  Cytochrome P450 DB1,  Cytochrome P450 family 2 subfamily D member 6,  Cytochrome P450 family 2 subfamily D polypeptide 6,  Debrisoquine 4 hydroxylase,  Flavoprotein linked monooxygenase,  Microso
Swissprot
Cellular Localization Endoplasmic reticulum membrane, Peripheral membrane protein, Microsome membrane, Peripheral membrane protein.
Concentration 0.2 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cardiovascular,  Metabolism,  Signal Transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Unconjugated

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