Cystatin E/CST6 Monoclonal Antibody (AN200026P)
For research use only.
| Verified Samples | Verified Samples in IHC: Human skin |
| Dilution | IHC-P 1:50-1:200, |
| Isotype | IgG1 |
| Host | Mouse |
| Reactivity | Human |
| Applications | IHC-P |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human Cystatin E / CST6 protein |
| Abbre | CST6 |
| Synonyms | CST 6, Cystatin 6, Cystatin E, Cystatin E/M, Cystatin M, Cystatin M/E, Cystatin6, Cystatin-6, CystatinE, Cystatin-E, CystatinM, Cystatin-M, Cysteine proteinase inhibitor, CYTM, CST6 |
| Swissprot | |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Research Areas | Cell Biology |
| Clone No. | A870 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | Cystatin E/M, also referred to as CST6, is a member of type 2 cysteine proteinase inhibitors of the cystatin superfamily, and inhibits papain and cathepsin B. Cystatin E is a low molecular mass secreted protein existing in both a glycosylated (17 kDa) and an unglycosylated (14 kDa) form, with two characteristic intrachain disulfide bridges. Expression of cystatin M/E is found to be restricted to the epidermis, more specifically in the stratum granulosum, sweat glands, sebaceous glands, and the hair follicles. In addition to its function as a cysteine protease inhibitor, cystatin M/E also serves as a target for cross-linking by transglutaminases. Accordingly, cystatin M/E was suggested to be involved in barrier formation and maintenance. Furthermore, studies have revealed that cystatin M/E is frequently epigenetically inactivated during breast carcinogenesis, and thus be regarded as a candidate of tumour suppressor gene. |
Other Clones
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Unconjugated
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