DAB2 Polyclonal Antibody (E-AB-14925)
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For research use only.
| Verified Samples |
Verified Samples in WB: Hela Verified Samples in IHC: Human tonsil, Human thyroid cancer |
| Dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human DAB2 |
| Abbre | DAB2 |
| Synonyms | 2, Dab, DAB 2, DAB2, Differentially expressed in ovarian cancer 2, Differentially expressed protein 2, Disabled, Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein), Disabled homolog, Disabled homolog 2, Disabled homolog 2 mitogen responsive phosphoprotein, Disabled homolog 2 mitogen responsive phosphoprotein (Drosophila), DOC 2, DOC2, Drosophila, FLJ26626, homolog 2 (Drosophila), homolog of, Mitogen responsive phosphoprotein抗体, mitogen-responsive phosphoprotein |
| Swissprot | |
| Calculated MW | 82 kDa |
| Cellular Localization | Cytoplasmic vesicle, Clathrin coated vesicle, Clathrin coated vesicle membrane, Cell membrane, Coated pit, Clathrin coated pit, Vesicles |
| Tissue Specificity | Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart and small intestine. Expressed in kidney proximal tubular epithelial cells (at protein level). |
| Concentration | 0.60 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20℃ Valid for 12 months. Avoid freeze/thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Product Recommendations for Literature Synchronization
Note: Data for this module come from published literature that cites this product, displaying other products used together in the same research paper.
| Cat.No. | Product Name | Sizes |
|---|---|---|
| E-AB-1003 | Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL |
| E-AB-1043 | Streptavidin(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL |
| E-AB-1194 | HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed | 500μL , 120μL , 1mL |
| E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 50mL , 18mL , 6mL , 3mL |
| E-IR-R220 | Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
| E-IR-R221 | Super Plus™ Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
| E-IR-R304A | Western Blot Detection Kit | 50Assays |
| E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |
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