DDX11 Polyclonal Antibody (E-AB-15165)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human ovarian cancer, Human breast cancer |
| Dilution | IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human DDX11 |
| Abbre | DDX11 |
| Synonyms | CHL1, CHL1 related helicase gene 1, CHL1-like helicase homolog, CHL1-related protein 1, CHLR1, DDX11, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11, DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like h, Ddx11 |
| Swissprot | |
| Cellular Localization | Nucleus. Nucleus>nucleolus. During the early stages of mitosis, localizes to condensed chromatin and is released from the chromatin with progression to metaphase. Also localizes to the spindle poles throughout mitosis and at the midbody at later stages of mitosis (metaphase to telophase). Co-localizes with bovine papillomavirus type 1 regulatory protein E2 at early stages of mitosis. |
| Concentration | 0.2 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cell Biology, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Other Clones
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Other Formats
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Unconjugated
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