DYNLL1 Polyclonal Antibody (E-AB-14954)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human thyroid cancer, Human esophagus cancer |
| Dilution | IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human DYNLL1 |
| Abbre | DYNLL1 |
| Synonyms | 8 kDa dynein light chain, 8kDLC, Cytoplasmic dynein light polypeptide, DLC1, DLC8, DNCL1, DNCLC1, DYL1, Dynein, Dynein light chain 1, Dynein light chain 1 cytoplasmic, Dynein light chain LC8 type 1, Dynein light chain LC8-type 1, cytoplasmic, light chain 1 |
| Swissprot | |
| Cellular Localization | Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Upon induction of apoptosis translocates together with BCL2L11 to mitochondria. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Neuroscience, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. |
Other Clones
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Other Formats
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Unconjugated
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