EIF3H Polyclonal Antibody (E-AB-14979)
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For research use only.
| Verified Samples |
Verified Samples in WB: Human adrenal pheochromocytoma, Human fetal brain Verified Samples in IHC: Human colon cancer, Human brain |
| Dilution | WB 1:500-1:2000, IHC 1:100-1:300 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human EIF3H |
| Abbre | EIF3H |
| Synonyms | EIF3H, EIF3S3, Eukaryotic translation initiation factor 3 subunit 3, Eukaryotic translation initiation factor 3 subunit H, MGC102958, eIF-3-gamma, eIF3 gamma, eIF3 p40, eIF3 p40 subunit, eIF3h |
| Swissprot | |
| Calculated MW | 40 kDa |
| Cellular Localization | Cytoplasm. |
| Concentration | 0.8 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. |
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