Elab Fluor^® 647 Anti-Mouse TNFα Antibody[XT3.11] (AN00567M)

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Cell Markers

Size	Price	Qty
100Tests	$ 92.00	- +
50Tests	$ 51.00	- +
100Tests×2	$ 166.00	- +

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Isotype	Rat IgG1, κ
Host	Rat
Reactivity	Mouse
Applications	ICFCM
Clonality	Monoclonal
Abbre	TNF-α
Synonyms	Tumor necrosis factor-α, Cachectin, Necrosin, Macrophage cytotoxic factor, Differentiation inducing factor, TNFSF-2, TNF-a, TNF-alpha
Swissprot	P06804
Cellular Localization	Secreted
Concentration	5 μL/Test
Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Clone No.	XT3.11
Conjugation	Elab Fluor^®647
Storage	This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Shipping	Ice bag
background	TNF-α is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells. Many transformed cell lines also secrete TNF-α. Monomeric mouse TNF-α is a 156 amino acid protein (N-glycosylated) with a reported molecular weight of 17.5 kD. TNF-α forms multimeric complexes; stable trimers are most common in solution. A 26 kD membrane form of TNF-α has also been described. TNF-α binding to surface receptors elicits a wide array of biologic activities including: cytolysis and cytostasis of many tumor cell lines in vitro, hemorrhagic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.

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