Elab Fluor® 700 Anti-Mouse CD206/MMR Antibody[C068C2] (E-AB-F1135UM1)
![Elab Fluor<sup>®</sup> 700 Anti-Mouse CD206/MMR Antibody[C068C2] - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
Conjugation: Elab Fluor®700
APC Elab Fluor®700 FITC PE PE/Cyanine 7 Unconjugated Show More
| Alternate Names | MMR, MR, MRC1, macrophage mannose receptor, mannose receptor |
| Clone | |
| Leadtime | Order now, ship in 3 days |
| Background | CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature. |
| Abbre | CD206 |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Isotype | Rat IgG2a, κ |
| Isotype Control | Elab Fluor® 700 Rat IgG2a, κ Isotype Control[2A3] |
| Applications |
FCM
|
| Cellular Localization |
Membrane;Endosome
|
| Form | Liquid |
| Concentration |
0.5 mg/mL
|
| Conjugation | Elab Fluor®700 |
| Conjugation Information | Elab Fluor® 700 is designed to be excited by the Red laser (627-640 nm) and detected using an optical filter centered near 719 nm (e.g., a 725/40 nm bandpass filter). |
| Spectrum | |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Storage | This product can be stored at 2-8°C for 24 months. Please protected from prolonged exposure to light and do not freeze. |
| Expiration Date | 24 months |
| Shipping | Ice bag |
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