Elab Fluor^® Violet 450 Anti-Mouse CD123 Antibody[5B11] (AN00962Q)

Name: Elab Fluor® Violet 450 Anti-Mouse CD123 Antibody[5B11]
Brand: Elabscience
SKU: AN00962Q
Price: 0.99 USD
Availability: InStock

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Elab Fluor<sup>®</sup> Violet 450 Anti-Mouse CD123 Antibody[5B11] - 1

Size	Price	Qty
100Tests	$ 55.00	- +
50Tests	$ 31.00	- +
10Tests	$ 0.99	- +
100Tests×2	$ 99.00	- +

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Isotype	Rat IgG2a
Host	Rat
Reactivity	Mouse
Applications	FCM
Clonality	Monoclonal
Abbre	CD123
Synonyms	IL-3 Receptor α chain, IL-3Rα
Swissprot	Q8CII2
Cellular Localization	Membrane
Concentration	5 μL/Test
Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Clone No.	5B11
Conjugation	Elab Fluor^® Violet 450
Storage	This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Shipping	Ice bag
background	CD123 is a 70 kD α chain subunit of the IL-3 receptor (IL-3R α). It is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind IL-3 with low affinity but cannot transduce signals without association with additional protein partners. CD123 can complex with either the common β chain (CDw131) or the IL-3R β chain (AIC2A) to form high-affinity heterodimeric IL-3 receptors. CDw131 can complex with the α subunits of the mouse IL-3R, IL-5R and GM-CSFR to form high-affinity receptors, while the IL-3 R β subunit is specific for IL-3 but binds with low affinity. IL-3 binding to the receptor complex can induce proliferation and differentiation of hematopoietic cells. The 5B11 antibody does not block binding of IL-3 to the high affinity IL-3 receptor.