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For research use only.

Verified Samples Verified Samples in WB: Mouse lung
Verified Samples in IHC: Human breast cancer
Dilution WB 1:1000-1:5000,  IHC 1:100-1:500
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse,  Rat
Applications WB,  IHC
Clonality Polyclonal
Immunogen Synthetic peptide of human FGF2
Abbre FGF2
Synonyms BFGF,  Basic fibroblast growth factor,  Basic fibroblast growth factor bFGF,  FGF 2,  FGF B,  FGF-2,  FGF2,  FGF2 basic,  FGFB,  Fgf2,  Fibroblast growth factor,  Fibroblast growth factor 2,  Fibroblast growth factor 2 (basic),  HBGF 2,  HBGF-2,  HBGF2,  HBGH 2,  HBGH2,  Heparin bindi,  basic
Swissprot
Calculated MW 31 kDa
Cellular Localization Secreted. Nucleus. Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.
Concentration 0.7 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer,  Cardiovascular,  Developmental Biology,  Neuroscience,  Signal Transduction,  Stem Cells
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
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Unconjugated

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