FITC Anti-Human CD279/PD-1 Antibody[EH12.2H7] (E-AB-F1229C)

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Cell Markers

Size	Price	Qty
100Tests	$ 174.00	- +
20Tests	$ 66.00	- +
100Tests×2	$ 264.00	- +

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Conjugation: FITC

Isotype	Mouse IgG1, κ
Host	Mouse
Reactivity	Human
Applications	FCM
Clonality	Monoclonal
Isotype Control	FITC Mouse IgG1, κ Isotype Control[MOPC-21]
Abbre	CD279/PD-1
Synonyms	PD1, PDCD1, Protein PD-1, hPD-1
Swissprot	Q15116
Cellular Localization	Membrane
Concentration	5 μL/Test
Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Research Areas	Cancer Biomarkers, Immunology, Inhibitory Molecules
Clone No.	EH12.2H7
Conjugation	FITC
Conjugation Information	FITC is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 530 nm (e.g., a 525/40 nm bandpass filter).
Spectrum
Storage	This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Shipping	Ice bag
background	Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.