FITC Anti-Mouse CD272/BTLA Antibody[PJ196] (AN00633C)
![FITC Anti-Mouse CD272/BTLA Antibody[PJ196] - 1](http://file.elabscience.com/assets/images/loading.png)
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For research use only.
Conjugation: FITC
| Isotype | Mouse IgG1, κ |
| Host | Mouse |
| Reactivity | Mouse |
| Applications | FCM |
| Clonality | Monoclonal |
| Isotype Control | FITC Mouse IgG1, κ Isotype Control[MOPC-21] |
| Abbre | CD272 |
| Synonyms | BTLA, B and T lymphocyte attenuator |
| Swissprot | |
| Cellular Localization | Membrane |
| Concentration | 5 μL/Test |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Clone | PJ196 |
| Conjugation | FITC |
| Conjugation Information | FITC is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 530 nm (e.g., a 525/40 nm bandpass filter). |
| Spectrum |
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| Storage | This product can be stored at 2-8°C for 24 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
| background | B and T lymphocyte attenuator (BTLA) is an Ig superfamily coinhibitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand Herpes Virus Entry Mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significant up-regulated expression of BTLA compared with effector and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It has been reported that BTLA may regulate T cell function through binding to B7-H4. |
| Cat.No. | Product Name | Clone No. |
|---|---|---|
| AN00415C | FITC Anti-Mouse CD272 Antibody[6F7] | 6F7 |
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