FITC Anti-Mouse/Rat Foxp3 Antibody[FJK-16s] (E-AB-F1351C)

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Size	Price	Qty
100Tests	$ 260.00	- +
50Tests	$ 140.00	- +
100Tests×2	$ 390.00	- +

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Isotype	Rat IgG2a, κ
Host	Rat
Reactivity	Mouse, Rat
Applications	ICFCM
Clonality	Monoclonal
Abbre	Foxp3
Synonyms	IPEXJM2ScurfinZinc finger protein JM2, Forkhead box protein P3
Swissprot	Q99JB6
Cellular Localization	Nucleus;Cytoplasm
Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Research Areas	Immunology
Clone No.	FJK-16s
Conjugation	FITC
Storage	This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Shipping	Ice bag
background	FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4<sup>+</sup>/CD25<sup>-</sup> cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity.

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E-CK-A105	10×ACK Lysis Buffer	500mL , 200mL , 100mL
E-CK-A107	Cell Staining Buffer	500mL , 200mL , 100mL
E-CK-A108	Foxp3/Transcription Factor Staining Kit	20Assays