FZD6 Polyclonal Antibody (E-AB-12926)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human thyroid cancer, Human gastric cancer |
| Dilution | IHC 1:100-1:300 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human FZD6 |
| Abbre | FZD6 |
| Synonyms | FZD 6, FZD6, Frizzled 6 seven transmembrane spanning receptor, Frizzled drosophila homolog of 6, Frizzled family receptor 6, Frizzled homolog 6, Frizzled homolog 6 (Drosophila), Frizzled-6, Frizzled6, Fz 6, Fz-6, Fz6, Fzd6, Hfz 6, NDNC10, hFz6 |
| Swissprot | |
| Cellular Localization | Membrane. Cell membrane. Cell surface. Apical cell membrane. Cytoplasmic vesicle membrane. Colocalizes with FZD3 at the apical face of cells (By similarity). |
| Concentration | 0.2 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Stem Cells |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide. |
Other Clones
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Other Formats
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Unconjugated
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