FZD8 Polyclonal Antibody (E-AB-16118)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Human esophagus cancer, Human liver cancer |
| Dilution | IHC 1:50-1:200 |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human FZD8 |
| Abbre | FZD8 |
| Synonyms | frizzled 8, Frizzled 8 seven transmembrane spanning receptor, Frizzled family receptor 8, Frizzled homolog 8, frizzled homolog 8 (Drosophila), Frizzled-8, FZ 8, Fz-8, FZ8, FZD 8, FZD8, hFZ 8, hFz8, HGNC4046, Homolog of Drosoph, seven transmembrane spanning receptor |
| Swissprot | |
| Cellular Localization | Membrane. Golgi apparatus. Cell membrane. Colocalizes with GOPC at the Golgi apparatus. |
| Concentration | 0.2 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Signal Transduction, Stem Cells |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. |
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