GRPR Polyclonal Antibody (E-AB-12444)
For research use only.
| Verified Samples |
Verified Samples in WB: Human hepatocellsular carcinoma, A549 Verified Samples in IHC: Human cervical cancer, Human esophagus cancer |
| Dilution | WB 1:200-1:1000, IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human GRPR |
| Abbre | GRPR |
| Synonyms | BB2, Bombesin BB2 receptor, GRP R, GRP preferring bombesin receptor, GRP-R, GRP-preferring bombesin receptor, GRPR, Gastrin Releasing Peptide Receptor, Gastrin-releasing peptide receptor, Grp/bombesin receptor, Grpr, bombesin receptor 2 |
| Swissprot | |
| Calculated MW | 43 kDa |
| Cellular Localization | Cell membrane. |
| Concentration | 1.1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Neuroscience, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. |
Other Clones
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Other Formats
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Unconjugated
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