HIF1AN Polyclonal Antibody (E-AB-13556)

For research use only.
Verified Samples |
Verified Samples in WB: Mouse brain, Mouse liver Verified Samples in IHC: Human esophagus cancer, Human brain |
Dilution | WB 1:500-1:2000, IHC 1:50-1:300 |
Isotype | IgG |
Host | Rabbit |
Reactivity | Human, Mouse |
Applications | WB, IHC |
Clonality | Polyclonal |
Immunogen | Synthetic peptide of human HIF1AN |
Abbre | HIF1AN |
Synonyms | DKFZp762F1811, FIH 1, FIH-1, FIH1, FLJ20615, FLJ22027 , Factor inhibiting HIF-1, Factor inhibiting HIF1, HIF1AN, HIF1N, Hyp, Hypoxia inducible factor 1 alpha inhibitor, Hypoxia inducible factor 1 alpha subunit inhibitor, Hypoxia inducible factor asparagine hydroxylase |
Swissprot | |
Calculated MW | 40 kDa |
Cellular Localization | Nucleus. |
Concentration | 0.6 mg/mL |
Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
Purification Method | Affinity purification |
Research Areas | Cancer, Epigenetics and Nuclear Signaling |
Conjugation | Unconjugated |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
background | Factor inhibiting HIF-1 (FIH-1) exists as a homodimer and binds to HIF-1alpha.Specifically, FIH-1 operates as an asparaginyl hydroxylase.It catalyzes the hydroxylation of the beta-carbon of Asparagine residue 803 within the carboxy terminal transactivation domain of HIF-1alpha.This hydroxylation event blocks the association of HIF-1alpha with co-activators.FIH-1 also binds to von Hippel-Lindau (VHL) tumor suppressor protein, which represses transcriptional ac-tivity of HIF-1alpha.In transiently transfected human osteosarcoma cells, FIH-1 localizes to the cytoplasm. |
Other Clones
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Other Formats
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Unconjugated
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