HSP40-4 Polyclonal Antibody (E-AB-11313)
For research use only.
| Verified Samples |
Verified Samples in WB: HepG2, Raji, A431, 231 Verified Samples in IHC: Human colon cancer, Human thyroid cancer |
| Dilution | WB 1:500-1:2000, IHC 1:100-1:300 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human DNAJA1 |
| Abbre | DNAJA1 |
| Synonyms | DJ 2, DJ2, DNAJ2, DNJA1, DjA1, DnaJ (Hsp40) homolog, DnaJ homolog subfamily A member 1, DnaJ protein homolog 2, Dnaja1, HDJ-2, HDJ2, HSDJ, HSJ-2, HSJ2, HSPF4, Heat shock 40 kDa protein 4, Heat shock protein J2, Hum, hDJ 2, heat shock protein DNAJ like 2, member 1, subfamily A |
| Swissprot | |
| Calculated MW | 45 kDa |
| Cellular Localization | Membrane. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling. |
Other Clones
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Other Formats
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Unconjugated
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