Human α2-M Antibody Pair Set (E-KAB-0526)
For research use only.
| Background |
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases , including trypsin , thrombin and collagenase. It can also inhibit inflammatory cytokines , and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease ( AD ) due to its ability to mediate the clearance and degradation of A-beta , the major component of beta-amyloid deposits. A related pseudogene , which is also located on the p arm of chromosome 12 , has been identified.
|
| Synonyms |
α2M, A2M
|
| Swissprot | |
| Reactivity |
Human
|
| Specificity |
Detects Human α2-M in ELISAs
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| Applications |
ELISA
|
| Storage |
-20℃
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| Expiration date |
12 months
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Other Clones
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