Human ADAMTS5 Antibody Pair Set (E-KAB-0505)
For research use only.
| Background |
Metalloproteinase that plays an important role in connective tissue organization , development , inflammation and cell migration. Extracellular matrix ( ECM ) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans ( CSPGs ) including ACAN , VCAN , BCAN and NCAN.Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development , including limb and cardiac morphogenesis , and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts , facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.Participates in development of brown adipose tissue and browning of white adipose tissue.Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.
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| Synonyms |
ADAMTS5, ADAM-TS 11, ADAM-TS 5, ADAM-TS5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADMP-2, ADAM metallopeptidase with thrombospondin type 1 motif 5
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human ADAMTS5 in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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Other Clones
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