Human CASP4 Antibody Pair Set (E-KAB-0492)
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For research use only.
| Background |
This gene encodes a member of the cysteine proteases that plays important roles in apoptosis , cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4 , apoptosis-related cysteine peptidase" , this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9.
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| Synonyms |
Caspase-4, CASP-4, ICE and Ced-3 homolog 2, ICH-2, ICE ( rel ) -II, Mih1, Protease TX, ICH2, TX
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human CASP4 in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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