Human HAVCR2 Antibody Pair Set (E-KAB-0437)
For research use only.
| Background |
T cell immunoglobulin and mucin domain-3 ( TIM3 ) , also called hepatitis A virus cellular receptor 2 ( HAVCR2 ) , isa transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important rolein the Th1-mediated immune response. TIM3 is expressed on the Th1 cells , CD8 T-cells , monocytes , anddendritic cells , but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosisof apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interactionwith phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressivefunctions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with anagonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is alsoregarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 ( PD-1 ) as twoimportant coinhibitory regulators of T cell responses , have been implicated with the T-cell dysfunction orexhaustion associated with chronic HBV infection including HBV-related HCC.
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| Synonyms |
T cell immunoglobulin and mucin domain containing protein 3, hepatitis virus cellular receptor 2, CD366
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human HAVCR2 in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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Other Clones
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