Human HBEGF Antibody Pair Set (E-KAB-0428)
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For research use only.
| Background |
Heparin-binding EGF-like growth factor ( HB-EGF ) is a 12-16 kDa member of the epidermal growth factor ( EGF ) family. It possesses an EGF-like domain , and a heparin-binding motif. Mature HB-EGF is a soluble peptide thatarises from proteolytic processing of the transmembrane form. Human HB -EGF shows 76% and 73% aasequence identity with rat and mouse HB-EGF , respectively. It is required for normal cardiac valve formationand normal heart function , promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation , it is mitogenic for fibroblasts , but not endothelial cells. HB-EGF classified as agroup 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activityassociated with ErbB4 binding appears to be limited to non -mitogenic actions , while EGFR binding inducesboth mitogenic and non-mitogenic activity.
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| Synonyms |
DTR, DTS, DTSF, Diphtheria Toxin Receptor, Diphtheria toxin receptor, HB-EGF, HEGFL, Proheparin-binding EGF-like growth factor
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human HBEGF in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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