Human IL-37 Antibody Pair Set (E-KAB-0719)
For research use only.
| Background |
IL-37,also known as IL-1F7,belongs to the IL-1 family. There are five isoforms generated by alternative splicing,identified as IL-37a-e. IL-37b is the largest isoform and IL-37a contains a unique N-terminal sequences,absent in other isoforms. IL-37 is exclusively expressed only in human cells,but not found in murine cells. IL-37 isoforms are expressed in a tissue-specific manner. Its expression is upregulated upon LPS stimulation as well as TLR agonists in human blood monocytes and macrophages,whereas it is downregulated by IL-12,IL-32 and combination of GM-CSF and IL-4. IL-37 has been shown to translocate to the nucleus upon LPS treatment. IL-37 is a broad anti-inflammatory cytokine. IL-37a and IL-37b inhibits LPS-treated pro-inflammatory cytokine production in M1-differentiated macrophages and dendritic cells via IL-18Rα and SIGIRR/IL-1R8.
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| Synonyms |
IL37, FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human IL-37 in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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| Introduction |
This ELISA kit applies to the in vitro quantitative determination of Human IL-37 concentrations in serum, plasma and other biological fluids.
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