Human OxLDL Antibody Pair Set (E-KAB-0163)
For research use only.
| Background |
Oxidized LDL (Ox-LDL) is a class of modified LDL. In addition to oxidation-modified LDL,modified LDL also includes acetylated LDL directly combined with malondialdehyde (MDA) and 4-hydroxylenic acid (4-HNE). These LDL which are not oxidation-modified but only chemically modified are called derived LDL. Different from derived LDL,Ox-LDL has unique physiological characteristics in the following aspects: (1) Ox-LDL can affect the metabolism of arachidonic acid and inhibit the esterification of cholesterol,but the derived LDL has no such effect,(2) Ox-LDL consumes endogenous antioxidant substances in LDL and reduces vitamin E content in LDL,while MDA-LDL has no such effect,(3) Oxidative modification involves lipid peroxidation,and PUFAs in LDL are oxidized,(4) When oxidized LDL is low in oxidation degree,ApoB degrades,When the oxidation degree is high,ApoB can be repolymerized. Ox-LDL is not metabolized by LDL receptors,and is recognized,bound,and endocytosed into cells by scavorator receptors. The normal cholesterol metabolism pathway is lost,resulting in intracellular lipid deposition and foam-like transformation.
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| Synonyms |
OL, Oxidized Low Density Lipoprotein
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| Reactivity |
Human
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| Specificity |
Detects Human OxLDL in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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| Introduction |
This Antibody Pair Kit applies to the sandwich ELISA assay.
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