Human PD-1 Antibody Pair Set (E-KAB-0461)
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For research use only.
| Background |
Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self.Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2.Following T-cell receptor ( TCR ) engagement , PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation.Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding , PDCD1 is phosphorylated within the ITSM motif , leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules , such as ZAP70 , PRKCQ/PKCtheta and CD247/CD3zeta.
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| Synonyms |
CD279, PD-1, PD1, SLEB2
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human PD-1 in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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