Human PD-1 Antibody Pair Set (E-KAB-0461)
For research use only.
| Background |
Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self.Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2.Following T-cell receptor ( TCR ) engagement , PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation.Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding , PDCD1 is phosphorylated within the ITSM motif , leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules , such as ZAP70 , PRKCQ/PKCtheta and CD247/CD3zeta.
|
| Synonyms |
CD279, PD-1, PD1, SLEB2
|
| Swissprot | |
| Reactivity |
Human
|
| Specificity |
Detects Human PD-1 in ELISAs
|
| Applications |
ELISA
|
| Storage |
-20℃
|
| Expiration date |
12 months
|
Other Clones
{{antibodyDetailsPage.numTotal}} Results
-
{{item.title}}
Citations ({{item.publications_count}}) Manual MSDS
Cat.No.：{{item.cat}}
{{index}} {{goods_show_value}}
Other Formats
{{formatDetailsPage.numTotal}} Results
Biotin
-
{{item.title}}
Citations ({{item.publications_count}}) Manual MSDS
Cat.No.：{{item.cat}}
{{index}} {{goods_show_value}}
-
IF：{{item.impact}}
Journal：{{item.journal}} ({{item.year}})
DOI：{{item.doi}}Reactivity：{{item.species}}
Sample Type：{{item.organization}}
-
Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}}
