Human PDGF-BB Antibody Pair Set (E-KAB-0495)
For research use only.
| Background |
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer ( PDGF-BB ) or as a heterodimer with the platelet-derived growth factor alpha polypeptide ( PDGF-AB ) , where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7 , at sites where this gene and that for COL1A1 are located , are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
|
| Synonyms |
PDGFBB
|
| Swissprot | |
| Reactivity |
Human
|
| Specificity |
Detects Human PDGF-BB in ELISAs
|
| Applications |
ELISA
|
| Storage |
-20℃
|
| Expiration date |
12 months
|
Other Clones
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