Human PECAM1/CD31 Antibody Pair Set (E-KAB-0531)
For research use only.
| Background |
Cell adhesion molecule which is required for leukocyte transendothelial migration ( TEM ) under most inflammatory conditions.Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment ( LBRC ) and is also essential for the LBRC membrane to be targeted around migrating leukocytes.Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions.Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils.Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal.Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells , PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes.
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| Synonyms |
CD31, CD31/EndoCAM, Cluster of differentiation 31, EndoCAM, GPIIA', PECA1, PECAM-1, Platelet endothelial cell adhesion molecule
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human PECAM1/CD31 in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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