Human sgp130 Antibody Pair Set (E-KAB-0405)
For research use only.
| Background |
The protein encoded by this gene is a signal transducer shared by many cytokines , including interleukin 6 ( IL6 ) , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) . This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6 , a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus , can bypass the interleukin 6 receptor ( IL6R ) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.
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| Synonyms |
CD130, CDW130, IL-6RB, IL6ST, IR6RB, Interleukin 6 signal transducer
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human sgp130 in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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Other Clones
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