Human SIRT1 Antibody Pair Set (E-KAB-0701)
For research use only.
| Background |
SIRT1,the human homolog of the S. cerevisiae Sir2 protein,functions as an NAD-dependent deacetylase of a number of nonhistone substrates including p53. In response to DNA damage,SIRT1 binds and deacetylates the p53 protein at c-terminal Lys382 residue and attenuates p53-mediated functions. When overexpressed in mouse embryo fibroblasts,SIRT1 antagonizes PML-induced acetylation of p53 and rescues PML-mediated premature cellular senescence. In mammalian cells,SIRT1 appears to control the cellular response to stress by regulating the FOXO family of forkhead transcription factors.
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| Synonyms |
SIR2L1, NAD-dependent deacetylase sirtuin-1
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human SIRT1 in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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| Introduction |
This ELISA kit applies to the in vitro quantitative determination of Human SIRT1 concentrations in serum, plasma and other biological fluids.
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