Human SOST Antibody Pair Set (E-KAB-0465)
For research use only.
| Background |
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like ( CTCK ) domain and sequence similarity to the DAN ( differential screening-selected gene aberrative in neuroblastoma ) family of bone morphogenetic protein ( BMP ) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder , sclerosteosis , which causes progressive bone overgrowth. A deletion downstream of this gene , which causes reduced sclerostin expression , is associated with a milder form of the disorder called van Buchem disease.
|
| Synonyms |
CDD, VBCH
|
| Swissprot | |
| Reactivity |
Human
|
| Specificity |
Detects Human SOST in ELISAs
|
| Applications |
ELISA
|
| Storage |
-20℃
|
| Expiration date |
12 months
|
Other Clones
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