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For research use only.

Verified Samples Verified Samples in IHC: Human lung cancer, Human prostate cancer
Dilution IHC 1:50-1:300
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse
Applications IHC
Clonality Polyclonal
Immunogen Fusion protein of human HUS1
Abbre HUS1
Synonyms S. pombe,   homolog of,  Checkpoint protein HUS1,  HUS1,  HUS1 (S. pombe) checkpoint homolog,  HUS1 Checkpoint Protein,  HUS1 checkpoint homolog (S. pombe),  HUS1 protein,  HUS1+ - like protein,  Hus1,  Hydroxyurea-sensitive 1,  hHUS1
Swissprot
Cellular Localization Nucleus. Cytoplasm. In discrete nuclear foci upon DNA damage. According to PubMed:14500360, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm.
Concentration 1.14 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Antigen affinity purification
Research Areas Cancer,  Epigenetics and Nuclear Signaling
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage.This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1.In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin.The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event.Alternative splicing results in multiple transcript variants.
Other Clones

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Unconjugated

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