IL10 Polyclonal Antibody (E-AB-70235)
For research use only.
| Verified Samples |
Verified Samples in IHC: Mouse lungs Verified Samples in IF: Rat Inflammatory lung |
| Dilution | IHC 1:200-1:1000, IF 1:200-1:1000 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Applications | IHC, IF |
| Clonality | Polyclonal |
| Immunogen | KLH conjugated Synthetic peptide corresponding to IL-10 |
| Abbre | IL10 |
| Synonyms | Interleukin, RP11-262N, CSIF, GVHDS, IL-10, IL10A, TGIF, IL10, Cytokine synthesis inhibitory factor, Interleukin-10, MGC126450, MGC126451, RP11-262N9.1 |
| Swissprot | |
| Cellular Localization | Secreted. |
| Concentration | 150 μg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Immunology |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. |
Other Clones
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Other Formats
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Unconjugated
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