IL13RA1 Polyclonal Antibody (E-AB-61258)
For research use only.
| Verified Samples |
Verified Samples in WB: HT29, 293T |
| Dilution | WB 1:500-1:2000 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Recombinant fusion protein of human IL13RA1 (NP_001551.1). |
| Abbre | IL13RA1 |
| Synonyms | CD213A, IL13RA1, CD213A1, CT19, IL-13Ra, NR4, IL13R, IL13RA, IL-13Ra1, alpha 1), bB128O4.2.1 (interleukin 13 receptor, Cancer/testis antigen 19, CD213A1 Antigen, CT 19, I13R1, IL 13 receptor subunit alpha 1, IL 13R alpha 1, IL 13R subunit alpha 1, IL 13Ra, IL 13RA1, IL13 receptor alpha 1 chain, IL-13 receptor subunit alpha-1, IL-13R subunit alpha-1, IL-13R-alpha-1, Interleukin 13 receptor alpha 1, Interleukin 13 receptor alpha 1 chain, interleukin 13 receptor subunit alpha 1, Interleukin-13 receptor subunit alpha-1, NR 4, NR4 |
| Swissprot | |
| Calculated MW | 31 kDa/48 kDa |
| Observed MW |
53 kDa
The actual band is not consistent with the expectation.
Western blotting is a method for detecting a certain protein in a complex sample based on the specific binding of antigen and antibody. Different proteins can be divided into bands based on different mobility rates. The mobility is affected by many factors, which may cause the observed band size to be inconsistent with the expected size. The common factors include: 1. Post-translational modifications: For example, modifications such as glycosylation, phosphorylation, methylation, and acetylation will increase the molecular weight of the protein. 2. Splicing variants: Different expression patterns of various mRNA splicing bodies may produce proteins of different sizes. 3. Post-translational cleavage: Many proteins are first synthesized into precursor proteins and then cleaved to form active forms, such as COL1A1. 4. Relative charge: the composition of amino acids (the proportion of charged amino acids and uncharged amino acids). 5. Formation of multimers: For example, in protein dimer, strong interactions between proteins can cause the bands to be larger. However, the use of reducing conditions can usually avoid the formation of multimers. If a protein in a sample has different modified forms at the same time, multiple bands may be detected on the membrane. |
| Cellular Localization | Membrane. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Immunology, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. |
Other Clones
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Other Formats
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Unconjugated
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