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For research use only.

Verified Samples Verified Samples in IHC: Human liver cancer, Human tonsil
Dilution IHC 1:30-1:150
Isotype IgG
Host Rabbit
Reactivity Human
Applications IHC
Clonality Polyclonal
Immunogen Synthetic peptide of human IL4R
Abbre IL4R
Synonyms 582J,  IL4R,  CD124,  IL-4RA,  IL4RA,  IL-4 receptor subunit alpha,  IL-4-binding protein,  IL4-BP,  IL-4R subunit alpha,  IL-4R-alpha,  Interleukin-4 receptor subunit alpha,  582J2.1,  IL-4R&,  alpha,  IL 4R alpha,  IL4R nirs variant 1,  IL4RA,  Interleukin 4 receptor,  Interleukin 4 receptor alpha chain,  sIL4Ralpha/prot,  Soluble IL-4 receptor subunit alpha,  Soluble IL-4R-alpha,  Soluble interleukin-4 receptor subunit alpha
Swissprot
Cellular Localization Secreted and Cell membrane.
Concentration 1.26 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Antigen affinity purification
Research Areas Cancer,  Immunology
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Other Clones

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Unconjugated

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