IPO4 Polyclonal Antibody (E-AB-11331)
For research use only.
| Verified Samples |
Verified Samples in WB: Hela, Human testis, A549, Jurkat, K562 Verified Samples in IHC: Human colon cancer, Human prostate cancer |
| Dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human IPO4 |
| Abbre | IPO4 |
| Synonyms | IPO4, Imp4, Imp4b, Importin 4, Importin 4b, Importin-4, Importin-4b, Ipo4, Ran binding protein 4, Ran-binding protein 4, RanBP4 |
| Swissprot | |
| Calculated MW | 119 kDa |
| Cellular Localization | Cytoplasm. Nucleus. |
| Concentration | 0.3 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Importin-4 is a protein that in humans is encoded by the IPO4 gene.Functions in nuclear protein import as nuclear transport receptor.Serves as receptor for nuclear localization signals (NLS) in cargo substrates.Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. |
Other Clones
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Other Formats
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Unconjugated
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