LATS2 Polyclonal Antibody (E-AB-15942)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Human thyroid cancer, Human liver cancer |
| Dilution | IHC 1:25-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human LATS2 |
| Abbre | LATS2 |
| Synonyms | FLJ13161, KPM, Kinase phosphorylated during mitosis protein, L, LATS large tumor suppressor Drosophila homolog 2, LATS large tumor suppressor homolog 2, Large tumor suppressor homolog 2, Large tumor suppressor homolog 2 Drosophila, Large tumor suppressor kinase 2 |
| Swissprot | |
| Cellular Localization | Cytoplasm>cytoskeleton>centrosome. Cytoplasm. Cytoplasm>cytoskeleton>spindle pole. Co-localizes with STK6 at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. |
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