LIMK1 Polyclonal Antibody (E-AB-13381)

For research use only.
Verified Samples |
Verified Samples in IHC: Human brain, Human thyroid cancer |
Dilution | IHC 1:50-1:200 |
Isotype | IgG |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Applications | IHC |
Clonality | Polyclonal |
Immunogen | Synthetic peptide of human LIMK1 |
Abbre | LIMK1 |
Synonyms | EC 2.7.1.37, LIM domain containing protein kinase, LIM domain kinase 1, LIM kinase, LIM motif containing protein kinase, LIMK, LIMK 1, LIMK-1, LIMK1, limk1 |
Swissprot | |
Cellular Localization | Cytoplasm. Cell projection>growth cone. |
Concentration | 0.9 mg/mL |
Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
Purification Method | Affinity purification |
Research Areas | Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Signal Transduction |
Conjugation | Unconjugated |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
background | There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. |
Other Clones
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Other Formats
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Unconjugated
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